{"id":1326,"date":"2022-11-16T11:19:12","date_gmt":"2022-11-16T11:19:12","guid":{"rendered":"https:\/\/alipanc.org\/grupo\/epithelial-carcinogenesis-group\/"},"modified":"2024-02-19T15:07:58","modified_gmt":"2024-02-19T15:07:58","slug":"epithelial-carcinogenesis-group","status":"publish","type":"grupo","link":"https:\/\/alipanc.org\/en\/grupo\/epithelial-carcinogenesis-group\/","title":{"rendered":"Epithelial Carcinogenesis Group &#8211; Francisco X Real Arribas"},"content":{"rendered":"<p>The work of our group focuses on three objectives:<\/p>\n<p>1. To identify the mechanisms that contribute in early stages to the development of pancreatic cancer. To this end, we use genetic mouse models that recapitulate human disease and focus on analyzing the role of cell differentiation processes and control of inflammation.<\/p>\n<p>2. To characterize the transcriptional regulatory programs involved in the phenotypic heterogeneity of pancreatic tumors, with a special emphasis on the control of the &#8220;classical&#8221; and &#8220;basal&#8221; programs. To this end, we used a combination of approaches including genetic mouse models of pancreatic cancer, human tumor organoids and cell lines.<\/p>\n<p>3. To identify new prognostic and\/or predictive markers that may be useful for the management of patients with pancreatic cancer. These studies use samples of patients with pancreatic cancer from various collaborative studies, mainly with N\u00faria Malats&#8217; group but also with various international groups.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>National Cancer Research Center (CNIO), Madrid, Spain<\/p>\n","protected":false},"featured_media":1205,"template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false},"investigacion":[55],"class_list":["post-1326","grupo","type-grupo","status-publish","has-post-thumbnail","hentry","investigacion-basic-translational"],"_links":{"self":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/grupo\/1326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/grupo"}],"about":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/types\/grupo"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/media\/1205"}],"wp:attachment":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/media?parent=1326"}],"wp:term":[{"taxonomy":"investigacion","embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/investigacion?post=1326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}