{"id":1330,"date":"2022-11-15T16:55:08","date_gmt":"2022-11-15T16:55:08","guid":{"rendered":"https:\/\/alipanc.org\/grupo\/molecular-targets-of-cancer\/"},"modified":"2026-01-12T06:30:13","modified_gmt":"2026-01-12T06:30:13","slug":"molecular-targets-of-cancer","status":"publish","type":"grupo","link":"https:\/\/alipanc.org\/en\/grupo\/molecular-targets-of-cancer\/","title":{"rendered":"Pancreatic cancer – Pilar Navarro and Fernando Burd\u00edo"},"content":{"rendered":"

\"\"<\/p>\n

This group includes two teams that carry out their research at the Hospital del Mar:<\/p>\n

The group of “Ablation therapies in oncologic surgery<\/strong>“directed by Fernando Burd\u00edo<\/strong>The primary objective of the scientific production and technological innovation<\/strong> in the field of applications of high frequency currents in the generation of heat in biological tissues, aimed at local cell destruction, minimally invasive<\/strong>of pathological tissues, especially (but not exclusively) of human neoplasms.<\/p>\n

https:\/\/www.imim.cat\/programesrecerca\/cancer\/es_thipertermia.html<\/a><\/p>\n

The “Molecular Targets of Cancer”<\/strong> group led by Pilar Navarro<\/strong> (IIBB-CSIC\/ Associated Unit Hospital del Mar Research Institute (HMRI)) has been exploring the molecular mechanisms of pancreatic cancer for more than 20 years with the aim of identifying new targets to improve early diagnosis<\/strong> and treatment<\/strong> of this tumor. For this purpose, we use cell and molecular biology techniques, in vitro functional assays and preclinical animal models that recapitulate the human pancreatic tumor and its microenvironment.<\/p>\n

Our most recent studies are focused on Galectin-1.<\/strong> as a biomarker and new therapeutic immune checkpoint (Mart\u00ednez-Bosch N et al. Oncotarget 2018; Mart\u00ednez-Bosch N et al. Cancer Res. 2014; Orozco CA et al. PNAS 2018; Navarro P et al. Clin Cancer Res. 2020), sAXL as an early biomarker of pancreatic cancer and differential diagnosis of chronic pancreatitis (Mart\u00ednez-Bosch N et al. eBioMed 2022) and the study of translational control as a new mechanism of gene reprogramming in this cancer (Ortiz-Zapater E et al. Nat Med. 2012; Villanueva E et al. Nat Comm. 2017; Jungfleisch J et al. Genome Res. 2017).<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Institute of Biomedical Research of Barcelona (IIBB-CSIC) \/ Associated Unit Hospital del Mar Research Institute (HMRI), Barcelona.<\/p>\n","protected":false},"featured_media":1909,"template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false},"investigacion":[55,54],"class_list":["post-1330","grupo","type-grupo","status-publish","has-post-thumbnail","hentry","investigacion-basic-translational","investigacion-clinical"],"_links":{"self":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/grupo\/1330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/grupo"}],"about":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/types\/grupo"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/media\/1909"}],"wp:attachment":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/media?parent=1330"}],"wp:term":[{"taxonomy":"investigacion","embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/investigacion?post=1330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}