{"id":3366,"date":"2026-06-29T11:13:31","date_gmt":"2026-06-29T11:13:31","guid":{"rendered":"https:\/\/alipanc.org\/grupo\/cancer-genetics-and-precision-medicine-zabra-lab\/"},"modified":"2026-06-29T11:13:31","modified_gmt":"2026-06-29T11:13:31","slug":"cancer-genetics-and-precision-medicine-zabra-lab","status":"publish","type":"grupo","link":"https:\/\/alipanc.org\/en\/grupo\/cancer-genetics-and-precision-medicine-zabra-lab\/","title":{"rendered":"Cancer Genetics and Precision Medicine \u2013 Zabra Lab"},"content":{"rendered":"<p>We aim to tackle pancreatic cancer dreadful reality by using in vivo and ex vivo models that faithfully recapitulate the genetic alterations commonly found in patients. In the lab, we have successfully developed and established orthotopic and metastatic syngeneic transplants using genetically-controlled organoids to then unravel tumor heterogeneity and resistance mechanisms from a very particular and unique context: the study of different single mutations in KRAS. This ubiquitous oncogene is altered in more than 95% of patients with pancreatic adenocarcinoma (PDAC).  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>We aim to tackle pancreatic cancer dreadful reality by using in vivo and ex vivo models that faithfully recapitulate the genetic alterations commonly found in patients. In the lab, we have successfully developed and established orthotopic and metastatic syngeneic transplants using genetically-controlled organoids to then unravel tumor heterogeneity and resistance mechanisms from a very particular [&hellip;]<\/p>\n","protected":false},"featured_media":3365,"template":"","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false},"investigacion":[55],"class_list":["post-3366","grupo","type-grupo","status-publish","has-post-thumbnail","hentry","investigacion-basic-translational"],"_links":{"self":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/grupo\/3366","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/grupo"}],"about":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/types\/grupo"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/media\/3365"}],"wp:attachment":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/media?parent=3366"}],"wp:term":[{"taxonomy":"investigacion","embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/investigacion?post=3366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}