{"id":1783,"date":"2025-02-25T09:39:43","date_gmt":"2025-02-25T09:39:43","guid":{"rendered":"https:\/\/alipanc.org\/?p=1783"},"modified":"2025-02-25T09:39:43","modified_gmt":"2025-02-25T09:39:43","slug":"new-paper-coauthored-by-an-alipanc-member-published-in-science","status":"publish","type":"post","link":"https:\/\/alipanc.org\/en\/new-paper-coauthored-by-an-alipanc-member-published-in-science\/","title":{"rendered":"New paper coauthored by an ALIPANC member published in Science"},"content":{"rendered":"<h5><strong>Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes<\/strong><\/h5>\n<p><span data-contrast=\"auto\">Type 2 diabetes is a significant risk factor for the development of pancreatic cancer, while obesity is a well-established risk factor for type 2 diabetes. However, the molecular mechanisms linking these two conditions has remained obscure until now.<\/span><span data-ccp-props=\"{}\">\u00a0<\/span><\/p>\n<p><span data-ccp-props=\"{}\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-1784 alignright\" src=\"https:\/\/alipanc.org\/wp-content\/uploads\/Imagen1-237x300.png\" alt=\"\" width=\"237\" height=\"300\" srcset=\"https:\/\/alipanc.org\/wp-content\/uploads\/Imagen1-237x300.png 237w, https:\/\/alipanc.org\/wp-content\/uploads\/Imagen1.png 473w\" sizes=\"(max-width: 237px) 100vw, 237px\" \/><\/span><\/p>\n<p><span data-ccp-props=\"{}\">This manuscript by Cho et al, in which the group of Alfredo Mart\u00ednez Ram\u00edrez has participated, has been recently published in <em>Science<\/em>. In this intensive work, the authors demonstrate that adipocytes (more abundant in obese people) secrete the regulatory peptide, adrenomedullin, which binds to its receptor in endothelial cells resulting in the activation of phosphatase PTP1B and in the blockade on the insulin receptor in these cells. This endothelial insulin resistance is a rather new concept and has important consequences in blood flow regulation. In addition, the authors have shown that using an adrenomedullin inhibitor is able to prevent insulin resistance even in obese mice, opening a door for pharmaceutical treatments to prevent type 2 diabetes initiation in overweight people.<\/span><\/p>\n<p>&nbsp;<\/p>\n<p>Read the full article here: <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adr4731\">https:\/\/www.science.org\/doi\/10.1126\/science.adr4731<\/a><\/p>\n<p>More about the group of <span data-contrast=\"auto\">Alfredo Mart\u00ednez Ram\u00edrez<\/span>:\u00a0<a href=\"https:\/\/alipanc.org\/grupo\/grupo-de-angiogenesis-alfredo-martinez-ramirez\/\">https:\/\/alipanc.org\/grupo\/grupo-de-angiogenesis-alfredo-martinez-ramirez\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes Type 2 diabetes is a significant risk factor for the development of pancreatic cancer, while obesity is a well-established risk factor for type 2 diabetes. However, the molecular mechanisms linking these two conditions has remained obscure until now.\u00a0 This manuscript by Cho et al, in which [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1783","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar"],"_links":{"self":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/posts\/1783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/comments?post=1783"}],"version-history":[{"count":5,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/posts\/1783\/revisions"}],"predecessor-version":[{"id":1808,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/posts\/1783\/revisions\/1808"}],"wp:attachment":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/media?parent=1783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/categories?post=1783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/tags?post=1783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}