{"id":3009,"date":"2025-12-16T22:31:25","date_gmt":"2025-12-16T22:31:25","guid":{"rendered":"https:\/\/alipanc.org\/?p=3009"},"modified":"2025-12-16T22:31:25","modified_gmt":"2025-12-16T22:31:25","slug":"new-potential-therapeutic-target-for-pancreatic-cancer-identified-by-alipanc-researchers","status":"publish","type":"post","link":"https:\/\/alipanc.org\/en\/new-potential-therapeutic-target-for-pancreatic-cancer-identified-by-alipanc-researchers\/","title":{"rendered":"New potential therapeutic target for pancreatic cancer identified by ALIPANC researchers"},"content":{"rendered":"<p>The study by Parejo-Alonso et al. identifies <strong>PPAR-\u03b4<\/strong> as a critical transcription factor mediating pancreatic cancer cell<strong> adaptation to microenvironmental stress<\/strong>.<\/p>\n<p>Normally involved in lipid metabolism, PPAR-\u03b4 is overexpressed in pancreatic tumors and, under metabolic stress, senses lipidomic alterations, triggering metabolic reprogramming that enhances glycolysis and promotes a pro-invasive phenotype.<\/p>\n<p>In vitro and in vivo models confirm that<strong> pharmacological inhibition of PPAR-\u03b4<\/strong> reverses these adaptations and reduces metastatic potential, highlighting its relevance as a <strong>promising therapeutic target<\/strong> for pancreatic cancer treatment.<\/p>\n<p>Complete information at the following <strong>link:<\/strong> https:\/\/pubmed.ncbi.nlm.nih.gov\/40607925\/<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The study by Parejo-Alonso et al. identifies PPAR-\u03b4 as a critical transcription factor mediating pancreatic cancer cell adaptation to microenvironmental stress. Normally involved in lipid metabolism, PPAR-\u03b4 is overexpressed in pancreatic tumors and, under metabolic stress, senses lipidomic alterations, triggering metabolic reprogramming that enhances glycolysis and promotes a pro-invasive phenotype. In vitro and in vivo [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":3008,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3009","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"_links":{"self":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/posts\/3009","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/comments?post=3009"}],"version-history":[{"count":1,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/posts\/3009\/revisions"}],"predecessor-version":[{"id":3011,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/posts\/3009\/revisions\/3011"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/media\/3008"}],"wp:attachment":[{"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/media?parent=3009"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/categories?post=3009"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/alipanc.org\/en\/wp-json\/wp\/v2\/tags?post=3009"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}