3D-PANC study protocol: Is three-dimensional imaging technology superior to computed tomography for assessing the response to neoadjuvant treatment in patients with borderline or locally advanced pancreatic adenocarcinoma?
This study focuses on improving the preoperative assessment of borderline or locally advanced pancreatic adenocarcinoma (PAC) after neoadjuvant chemotherapy, as conventional computed tomography (CT) has been shown to have very low accuracy in determining which patients will benefit from surgical resection. The hypothesis proposes that applying 3D-MSP (Model for Surgery Planning) technology to CT images will significantly increase accuracy in identifying resectable patients.
The primary objective of the study is to compare the accuracy of 3D-MSP with standard CT, focusing on the diagnosis of post-chemotherapy vascular involvement (venous and/or arterial). To achieve this, a prospective multicenter study is planned that will include, over a one-year period, all patients with PAC undergoing neoadjuvant therapy followed by surgical exploration. The diagnostic accuracy of both techniques (3D-MSP and CT) will be evaluated by comparing their results with intraoperative findings and final histopathological analysis.
Additionally, the study aims to analyze the accuracy of 3D-MSP in demonstrating response to chemotherapy, assess the impact of radiomics (quantitative texture analysis), and validate the usefulness of this three-dimensional technology for education, patient communication, and detailed surgical planning.
Marina Garcés Albir, Francisco García García, Isabel Mora Oliver, Elena Muñoz Forner, Luis Sabater Orti, Dimitri Dorcaratto; GRUPO 3D-PANC Integrantes Grupo 3D-PANC
Department of General and Digestive Surgery, Hospital Clínico Universitario de Valencia, Valencia, Spain; Department of General and Digestive Surgery, School of Medicine, University of Valencia, Valencia, Spain; INCLIVA: Biomedical Research Institute, Valencia, Spain.
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