ALIPANC researchers demonstrate that functionalization of lipid nanoparticles with “don’t eat me signal” blocking antibodies, such as the CD47/SIRP axis

α, result in a further increase of macrophage phagocytic activity on tumor cells.

In addition, enrichment of inflammatory M1 macrophages in preclinical PDAC models is achieved. These nanoparticles doubly functionalized with folate and the aCD7 antibody (LNP-FA-aCD7) allow the specific and efficient delivery of therapeutic mRNAs.

Pares et al. Biomed Pharmacother. 2026, 194:118919
https://www.sciencedirect.com/science/article/pii/S0753332225011138?via%3Dihub