Angiogenesis Group
Basic/translational research
Center for Biomedical Research of La Rioja (CIBIR)
·Logroño, La Rioja, Spain ·

The Angiogenesis Group is part of the Oncology Area of the Biomedical Research Center of La Rioja (CIBIR), located in Logroño, Spain. As the name implies, the Angiogenesis Group focuses on the process of angiogenesis in relation to cancer and other relevant diseases in which hypoxia and pathological growth of blood vessels contribute to disease initiation and progression. The Group has contributed to the knowledge of a poorly understood family of angiogenic peptides, including adrenomedullin and the N-terminal 20 peptide of proadrenomedullin, through cellular and molecular biology as well as genetic (inducible Knock-out models) paradigms, characterizing their involvement in cancer and metastasis formation.

In addition, the Group is very interested in the discovery and application of biomarkers for the early detection of pancreatic cancer and holds several patents related to this topic. Due to its insidious nature, pancreatic cancer is often detected in advanced stages, which significantly reduces the chances of effective treatment. On the other hand, patients whose cancer is detected in early stages have a much higher chance of survival. Therefore, developing and validating a protocol for early detection represents today the best opportunity to increase survival among pancreatic cancer patients.

Main publications in pancreatic cancer:

  1. Martínez-Moral, MP, Tena MT, Martín-Carnicero A, Martínez A. Highly sensitive serum volatolomic biomarkers for pancreatic cancer diagnosis. Clinica Chimica Acta. 2024; 557: 117895, 10.1016/j.cca.2024.117895.
  2. Corzana F, Asín A, Eguskiza A, de Tomi E, Martín-Carnicero A et al. Detection of tumor-associated autoantibodies in the sera of pancreatic cancer patients using engineered MUC1 glycopeptides. Ang Chemie Int Ed. 2024; e202407131, 10.1002/anie.202407131
  3. Del Campo-Pedrosa R, Martín-Carnicero A, González-Marcos A, Martínez A. New model to predict survival in advanced pancreatic ductal adenocarcinoma patients by measuring GGT and LDH levels and monocyte count. Frontiers in Oncology. 2024; 14: 11096, 10.3389/fonc.2024.1411096
Alfredo Martínez Ramírez

Principal Investigator

Group members

- Alfredo Martínez Ramírez
- Sonia Martínez Herrero
- Laura Ochoa Callejero
- Josune García Sanmartín
- Tom Kalathil Raju
- Srdjan Tadic
- Adrián Casas Benito
- Pablo Garrido Rodríguez
- Judit Narro Íñiguez
- Alfonso Martín Carnicero

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