Cancer Biochemistry
Basic/translational research
Department of Biology - University of Girona
·Girona ·

The Cancer Biochemistry group is a multidisciplinary group that brings together basic and clinical cancer research, with extensive experience in glycobiology and cancer.

The group’s research focuses on the field of cancer diagnosis and therapy. Specifically, work is being done to find molecular markers that allow cancer to be diagnosed at earlier stages, where current therapies are more effective, and that can also be used to improve prognosis and tumor monitoring; and in the study of glycoenzymes involved in adhesion, migration and metastasis processes, in order to be able to influence their effects:

    • Tumor markers: Abnormal glycosylation of serum proteins as possible tumor markers of carcinomas. Currently focused on pancreatic and prostatic carcinomas, specifically on the abnormal glycosylation of serum glycoproteins overexpressed or neo-expressed in pancreatic cancer, and of PSA (prostate-specific antigen). Extensible to other glycoproteins (Targeted glycoproteomics).

 

  • Molecular mechanisms responsible for glycosylation changes in tumors and targeted therapy against specific glycosyltransferases. Expression studies of glycosyltransferases responsible for the biosynthesis of tumor-associated glycosyl antigens, determination of their involvement in different stages of tumor progression, of the factors that regulate their expression, and analysis of the effects of inhibition of these glycosyltransferases in cellular and animal models.

Main publications in pancreatic cancer:

  1. Miró L, López J, Guerrero PE, Martínez-Bosch N, Manero-Rupérez N, Moreno M, Ortiz MR, Llop E, Navarro P, Peracaula R. Sialyltransferase Inhibitor Ac53FaxNeu5Ac Reverses the Malignant Phenotype of Pancreatic Cancer Cells, and Reduces Tumor Volume and Favors T-Cell Infiltrates in Mice. Cancers (Basel). 2022 Dec 12;14(24):6133. doi: 10.3390/cancers14246133. 
  2. Duran A, Guerrero PE, Ortiz MR, Pérez Del Campo D, Castro E, Garcia-Velasco A, Fort E, de Llorens R, Saldova R, Llop E, Peracaula R. Characterization of Mesothelin Glycosylation in Pancreatic Cancer: Decreased Core Fucosylated Glycoforms in Pancreatic Cancer Patients' Sera. Biomedicines. 2022 Aug 10;10(8):1942. doi: 10.3390/biomedicines10081942. 
  3. Guerrero PE, Miró L, Wong BS, Massaguer A, Martínez-Bosch N, Llorens R, Navarro P, Konstantopoulos K, Llop E, Peracaula R. Knockdown of α2,3-Sialyltransferases Impairs Pancreatic Cancer Cell Migration, Invasion and E-selectin-Dependent Adhesion. Int J Mol Sci. 2020 Aug 28;21(17):6239. doi: 10.3390/ijms21176239. 
Dr. Rosa Peracaula Miro

Principal Investigator

Group members

  • Dra. Rosa Peracaula Miro
  • Esther Llop
  • Rafael de Llorens
  • Adrià Duran
  • Anna Gratacós
  • Júlia López
  • Adelaida Garcia-Velasco
  • Ernesto Castro
  • Esther Fort
  • Maria Rosa Ortiz
  • Dúnia Pérez del Campo

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