Molecular Oncology
Basic/translational research
Francisco de Vitoria University (UFV)
·Madrid ·

The Molecular Oncology group of the Universidad Francisco de Vitoria-Hospital 12 de Octubre (UFV-H12O) is interested in exploring the pathophysiology of pancreatic ductal adenocarcinoma (PDAC) and the search for new therapeutic targets to improve the treatment of this type of tumor. To this end, we have focused on the study of transcriptional programs and epigenetic regulation of biological processes related to the development and progression of this type of tumor, such as cell proliferation, metabolic reprogramming and modification of the tumor microenvironment. Specifically, our group has focused on the study of the transcription factor c-MYC -amplified and/or overexpressed in ADP- and chromatin remodelers necessary for its transcriptional activity.

Main publications in pancreatic cancer:

  1. Velasco RM, Sánchez PJ, García AG, et al. Targeting BPTF Sensitizes Pancreatic Ductal Adenocarcinoma to Chemotherapy by Repressing ABC-Transporters and Impairing Multidrug Resistance (MDR). Cancers. 2022; 14(6): 1518. https://doi.org/10.3390/cancers14061518.  
  2. Velasco RM, García AG, Sánchez PJ, et al. Tumor microenvironment and heterotypic interactions in pancreatic cancer. J Physiol Biochem. 2022; 79(1): 1-14. doi:10.1007/s13105-022-00875-8. 
  3. Sánchez-Arévalo Lobo VJ, Fernandez LC, Carrillo-de-Santa-Pau E, et al. c-Myc down-regulation is required for the deployment of the pancreatic acinar transcriptional program. Gut. 2018; 64(4): 707-718. doi.10.1136/gutjnl-2016-312306 
Víctor Sánchez-Arévalo

Principal Investigator

Group members

  • Raul Muñoz Velasco 
  • Ana Garcia Garcia 
  • Maria Ferrer Aporta 
  • German Vallejo Palma 
  • Antonio Giraldez 
  • Ramon Gonzalez 
  • Daniela D’Empaire Altimari 
  • Esther Polanco 
  • Paula Pena Gonzalez 
  • Lucia Gozalo 
  • Lis Senach Rasilla 
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