Our team studies the biology of normal pancreatic tissue as essential knowledge for understanding the cellular and medical “drama” associated with the development of pancreatic cancer. Specifically, we study ductal cells and the role they play in pancreatic regeneration and exocrine pathogenesis, including pancreatic cancer. The main project we have related to PDAC is focused on the cell of origin. We have generated new lineage-tracing mouse lines from previously unknown ductal populations to study the early stages and development of ductal-derived pancreatic tumors and define early biomarkers and novel therapies by using in vivo and organoid models of mouse and human PDAC samples.