Our team studies the biology of normal pancreatic tissue as essential knowledge for understanding the cellular and medical “drama” associated with the development of pancreatic cancer. Specifically, we study ductal cells and the role they play in pancreatic regeneration and exocrine pathogenesis, including pancreatic cancer. The main project we have related to PDAC is focused on the cell of origin. We have generated new lineage-tracing mouse lines from previously unknown ductal populations to study the early stages and development of ductal-derived pancreatic tumors and define early biomarkers and novel therapies by using in vivo and organoid models of mouse and human PDAC samples.
Translational Medical Oncology and Individualized Cancer Therapy – Andrés Muñoz
The Hospital General Universitario Gregorio Marañón, the hospital to which this group belongs, has extensive experience within the multidisciplinary cancer unit in the treatment of this disease in its different stages. different stages. The generic objective of...