Translational Research in Digestive Tract Diseases (GITEAD)
Clinical research
Institute for Health Research. Santiago de Compostela University Hospital Complex
·Santiago de Compostela ·

The Translational Research Group in Digestive Diseases designs and carries out clinical and translational research projects in the area of Gastroenterology and Hepatology. Our interests are focused on diseases of the pancreas, mainly chronic pancreatitis and pancreatic cancer, inflammatory bowel disease and gastric cancer. Part of the group is focused on liver diseases, mainly liver cancer. The main areas of research are:

  • Pancreas:
    • Impact of exocrine pancreatic insufficiency in subjects with chronic pancreatitis and pancreatic cancer: survival and clinical consequences.
    • Identification of specific molecular biomarkers of chronic pancreatitis.
    • Identification of biomarkers for early detection of pancreatic cancer in asymptomatic high-risk individuals.
    • New therapeutic targets in pancreatic cancer: role of the obestatin/GPR39 system.
  • Inflammatory Bowel Disease:
    • Role of microbiota and intestinal bacterial profiles in the etiopathogenesis of inflammatory bowel disease (IBD).
    • Molecular basis of IBD-associated arthritis.
    • Characterization of the inflammatory response and its etiopathogenic role in IBD.
    • Personalized medicine based on activation of four inflammatory pathways to predict response to treatment of ulcerative colitis.
  • Gastric Cancer:
    • Biofluid metabolomic studies of patients with uninvestigated dyspepsia.
    • Identification of endogenous systems involved in the mitogenesis of gastric cancer cells.
  • Hepatology:
      • Viral hepatitis
      • Factors associated with the progression of fatty liver disease.
      • Impact of hepatocellular carcinoma and its local percutaneous treatment on the survival of patients on waiting lists for liver transplantation.

Main publications in pancreatic cancer:

  1. Domínguez-Muñoz JE, Nieto-Garcia L, López-Díaz J, et al. Impact of the treatment of pancreatic exocrine insufficiency on survival of patients with unresectable pancreatic cancer: a retrospective analysis. BMC Cancer. 2018;- 18(1): 534. doi: 10.1186/s12885-018-4439-x. PMID: 29728096
  2. Lariño-Noia J, Fernández RM, Novo MP, et al. Emergent endoscopic ultrasound-guided cholecystoduodenostomy does not prevent R0 resection in a pancreaticoduodenectomy for pancreatic cancer. Clin J Gastroenterol. 2022; 15(1): 263-267. doi: 10.1007/s12328-021-01540-1. Epub 2021 Oct 25. PMID: 34694600
  3. Iglesias-Garcia J, Lindkvist B, Lariño-Noia J, et al. Differential diagnosis of solid pancreatic masses: contrast-enhanced harmonic (CEH-EUS), quantitative-elastography (QE-EUS), or both? United European Gastroenterol J. 2017; 5(2): 236-246. doi: 10.1177/2050640616640635. Epub 2016 Jun 23. PMID: 28344791
Juan Enrique Domínguez Muñoz
Juan Enrique Dominguez Muñoz

Principal Investigator

Group members

  • Juan Enrique Domínguez Muñoz
  • Yolanda Pazos Randulfe
  • Yessica Domínguez Novoa

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