We aim to tackle pancreatic cancer dreadful reality by using in vivo and ex vivo models that faithfully recapitulate the genetic alterations commonly found in patients. In the lab, we have successfully developed and established orthotopic and metastatic syngeneic transplants using genetically-controlled organoids to then unravel tumor heterogeneity and resistance mechanisms from a very particular and unique context: the study of different single mutations in KRAS. This ubiquitous oncogene is altered in more than 95% of patients with pancreatic adenocarcinoma (PDAC).
Glycoimmunology Laboratory – Gabriel Rabinovich
The Glycoimmunology Laboratory, led by Dr. Gabriel Rabinovich and currently based at the CaixaResearch Institute (Barcelona), investigates immunoregulatory circuits mediated by lectinin a wide variety of pathological contexts, including cancer, autoimmune diseases,...