The vision and mission of the Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), is to achieve personalized cancer prevention. Although we participate in projects on different cancers, our interests are focused on pancreatic and urinary bladder cancer. The scope of the research carried out by the Group ranges from the identification of etiological agents and mechanisms, to the translation of the findings for cancer prevention in the general population and for the clinical management of patients. We apply a wide variety of data, biomarkers, images and omics (molecular big data) that, in combination with state-of-the-art analytical tools and data integration methods allow us to identify risk factors, characterize genetic susceptibility patterns and cancer subtypes and, thus, define the population at risk of developing these cancers. In addition, we are involved in the evaluation of clinical and public health strategies for cancer control using genomic data.