Nutrition Epidemiology Unit
Basic/translational research
Miguel Hernández University (UMH)
·Alicante ·

The EPINUT group is a multidisciplinary group composed of medical, nutritionist, nursing and other public health professionals. His main interest is focused on investigating the relationships of diet with major chronic non-communicable diseases, including cancer. In relation to pancreatic cancer, the principal investigator of the group conducted in the late 1990s a multi-cohort study on esophageal, stomach and pancreatic cancers, in which information was collected for some 199 esophageal, 414 stomach, and 165 pancreatic confirmed cases and 455 controls to investigate the main known risk factors such as tobacco and alcohol consumption, and other sociodemographic and lifestyle factors, with special interest in dietary factors. Asimismo, el grupo se ha incorporado al consorcio internacional PANC4 para investigar los factores de riesgo para el cáncer de páncreas agrupando los datos de los estudios realizados a nivel mundial.

At present, we are further investigating the effect of dietary factors on the risk of pancreatic cancer, based on dietary assessment using validated food frequency questionnaires (FFQ) that allow us to analyze the effect of food and nutrient intake and dietary patterns such as adherence to the Mediterranean diet and vegetarian patterns, and the more recently proposed EAT-Lancet pattern.

The group has a great capacity and experience in carrying out dietary assessment in epidemiological studies using validated CFA and specific software under intellectual property that we disseminate from the BIBLIODIETA platform on the group’s website (, which allows estimating habitual intake in the past and in the long term, and elaborating the main food quality indexes and dietary patterns.

Main publications in pancreatic cancer:

  1. Oncina-Cánovas A, González-Palacios S, Notario-Barandiaran L, et al. Adherence to Pro-Vegetarian Food Patterns and Risk of Oesophagus, Stomach, and Pancreatic Cancers: A Multi Case-Control Study (The PANESOES Study). Nutrients. 2022 Dec 12;14(24):5288. doi: 10.3390/nu14245288. PMID: 36558447; PMCID:PMC9787989.
  2. Rosato V, Negri E, Bosetti C, et al. Gallbladder disease, cholecystectomy, and pancreatic cancer risk in the International Pancreatic Cancer Case-Control Consortium (PanC4). Eur J Cancer Prev. 2020 Sep;29(5):408-415. doi: 10.1097/CEJ.0000000000000572. PMID: 32740166.
  3. Santibañez M, Vioque J, Alguacil J, de la Hera MG, et al. Occupational exposures and risk of pancreatic cancer. Eur J Epidemiol. 2010 Oct;25(10):721-30. doi: 10.1007/s10654-010-9490-0. Epub 2010 Jul 17. PMID: 20640489.
Jesus Vioque Lopez

Principal Investigator

Group members

  • Jesus Vioque Lopez
  • Manoli García de la Hera,
  • Laura Torres Collado
  • Sandra González Palacios
  • Laura Compañ Gabucio
  • Alejandro Oncina Cánovas
  • Antonio Signes Pastor
  • Leyre Notario Barandiarán

Other groups