Our line of research focuses on gaining a better understanding of the heterogeneity that exists in pancreatic cancer tumors from different patients. Understanding how different tumor cell identities are regulated and how they define complex interactions with the tumor microenvironment are part of the questions our research aims to answer. For this purpose, we use state-of-the art omics analyses (transcriptomics and epigenetics), which we complement with functional studies using primary in vitro and in vivo models.
Cancer Genetics and Precision Medicine – Zabra Lab
We aim to tackle pancreatic cancer dreadful reality by using in vivo and ex vivo models that faithfully recapitulate the genetic alterations commonly found in patients. In the lab, we have successfully developed and established orthotopic and metastatic syngeneic...