Pancreatic Cancer Research Group IDIBAPS - Clínic Barcelona
Basic/translational research | Clinical research
IDIBAPS-Clínic Barcelona
·Barcelona ·

The pancreatic cancer research group at IDIBAPS-Clinic Barcelona is a multidisciplinary group that brings together researchers with very complementary profiles and experiences ranging from clinical research, in its multiple specialties, to basic research.

The main lines of research of the group are focused on:

To deepen the pathophysiological knowledge of pancreatic cancer and to understand the underlying molecular mechanisms. We are interested in advancing our understanding of the involvement of the pancreatic stroma in carcinogenesis and especially in the cross-talk between neoplastic cell and tumor fibroblasts.

2. Discovery of new biomarkers for diagnosis, prognosis and predictive of survival or response to treatment.

3. Development of organoid models from surgical specimens and endoscopically guided biopsy. Establishment of more complex 3D culture models including tumor organoids and stromal cells.

4. Development of experimental therapies and preclinical studies in ex vivo and animal models. Therapies based on oncolytic virotherapy or nano-immunomedicines.

5. Innovation in endoscopic and surgical techniques to advance diagnosis and treatment.

Main publications in pancreatic cancer:

  1. Luna J, Boni J, Cuatrecasas M, Bofill-De Ros X, Núñez-Manchón E, Gironella M, Vaquero EC, Arbones ML, de la Luna S, Fillat C. DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumor growth. Gut. 2019 Aug;68(8):1465-1476.
  2. Sangrador I, Molero X, Campbell F, Franch-Expósito S, Rovira-Rigau M, Samper E, Domínguez-Fraile M, Fillat C, Castells A, Vaquero EC. Zeb1 in Stromal Myofibroblasts Promotes Kras-Driven Development of Pancreatic Cancer. Cancer Res. 2018 May 15;78(10):2624-2637. doi: 10.1158/0008-5472.CAN-17-1882. Epub 2018 Feb 28. PMID: 29490942.
  3. Pedrosa L, Araujo IK, Cuatrecasas M, Soy G, López S, Maurel J, Sánchez-Montes C, Montironi C, Saurí T, Sendino O, Pérez FM, Ausania F, Fernández-Esparrach G, Espósito FM, Vaquero EC, Ginès A. Targeted transcriptomic analysis of pancreatic adenocarcinoma in EUS-FNA samples by NanoString technology. Front Mol Biosci. 2023 May 17;10:1161893. doi: 10.3389/fmolb.2023.1161893. PMID: 37266332; PMCID: PMC10230066.
Cristina Fillat
Eva Vaquero

Principal Investigator

Group members

  • Fabio Ausania (co-IP)
  • Leticia Moreira (co-IP)
  • Tamara Saurí (co-IP)
  • Àngels Ginès 
  • Meritxell Gironella 
  • Oriol Sendino 
  • Carolina González 
  • Guillem Soy 
  • Lina Maria Candia 
  • Juan Ramon Ayuso 
  • Ivan Archilla 
  • Francesc Estrany 
  • Marta Parés 
  • Anna Mateu 
  • Marc Otero 
  • Silvia Pascual 
  • Eulàlia Segur-Bailach 

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