by Comite Web | Dec 10, 2025 | Sin categorizar
A study led by the Experimental Oncology Group at the Spanish National Cancer Research Centre (CNIO) has described a triple-combination therapy for pancreatic cancer. The work has been published in the prestigious journal Proceedings of the National Academy of Sciences (PNAS).
The study shows that genetic ablation of three key nodes in KRAS signaling (RAF1, EGFR, and STAT3) leads to complete and permanent regression of orthotopic PDAC tumors driven by KRAS/TP53 mutations. Similarly, a drug combination targeting KRAS (RMC-6236/daraxonrasib), EGFR (afatinib), and STAT3 (SD36) induces full tumor regression with no resistance observed for over 200 days. This triple therapy proved effective in both genetically engineered mouse models and patient-derived xenografts, without tumor relapse. Importantly, the treatment was well tolerated. Although the findings support the development of clinical trials based on this combined strategy to improve PDAC therapy, alternatives to afatinib and SD36 will be needed to facilitate clinical translation by reducing toxicity and improving ADME properties, respectively.
This finding opens the door to exploring these therapeutic avenues and guiding the development of new clinical trials that could benefit patients with pancreatic ductal adenocarcinoma.
Link to ➡️ Full article
Links to Research group ➡️ Experimental Oncology ALIPANC, Experimental Oncology CNIO.
by Comite Web | Dec 9, 2025 | Sin categorizar
On December 2, 2025, ALIPANC held its Extraordinary General Assembly to ratify the results of the electoral process for the Management Committee. The online voting system ensured transparency and participation, reaching 58% of elegible voting groups.
Management Committee 2025-2026
The 13 elected members are:
Francisco X. Real, Teresa Macarulla, Justo Castaño, Jorge Adeva, Alfredo Carrato, Silve Vicent Cambra, Elisa Espinet, Meritxell Rovira, Raquel Benítez, Francisco Barriga, Fabio Ausania, Carmen Guerra and Andrés Muñoz.
This team combines profiles in basic research (61.54%) and clinical research (38.46%), reinforcing a comprehensive approach to pancreatic cancer.
Next steps
In the coming days, positions (President, Vice-President, Secretary, Treasurer and Members) will be assigned, and the strategic plan for 2026 will be defined.
by Comite Web | Dec 9, 2025 | Sin categorizar
On November 21, ALIPANC held its 4th Solidarity Gala Dinner at the Élkar restaurant in Madrid, coinciding with World Pancreatic Cancer Day. The main goal was to raise funds to boost pancreatic cancer research, a disease that remains one of the greatest challenges in oncology.
An event to unite science and solidarity
The gala brought together healthcare professionals, researchers, patients, and partners in a unique gastronomic space with spectacular city views. The evening included a welcome cocktail, an institutional update on research progress, and a solidarity dinner.
During the event, patient experiences were shared, and current challenges in the diagnosis and treatment of pancreatic cancer were addressed. The highlight was the charity raffle and auction, featuring exclusive products and artworks donated by companies and artists.
Participation and collaboration
The dinner gathered 46 in-person attendees and 20 virtual participants (Fila 0), demonstrating the commitment of the scientific and social community. All funds raised will be allocated entirely to research projects promoted by ALIPANC.
Among the collaborating companies were Casa Mas, Leroy Merlin, One Shot Hotels, Seaside Hotels, INMOA and Deoleo. The works auctioned were by artists such as Jordi Franquesa, Ken Moser, Pierre Savater and Juan Pita.
by Comite Web | Dec 4, 2025 | Sin categorizar
Title: Results of VIRAGE trial: a randomized Phase IIb, open-label, study of Nab-Paclitaxel and Gemcitabine with/without intravenous VCN-01 in Patients with Metastatic Pancreatic Cancer
Speaker: Dr. Manel Cascalló, CEO of Theriva Biologics
About Dr. Manel Cascalló
Dr. Manel Cascalló, PhD, is the General Director for Europe at Theriva Biologics and former CEO of VCN Biosciences, a pioneering company in oncolytic virotherapy. He holds a Ph.D. in Molecular Biology from the University of Barcelona and completed advanced training at MD Anderson Cancer Center in the United States.
With more than 12 years of leadership experience in biotech, Dr. Cascalló is a recognized expert in the clinical development of oncolytic adenoviruses. He has authored numerous peer-reviewed publications and is the inventor of several patents that have advanced viral therapies for hard-to-treat cancers. His work has been instrumental in the development of VCN-01, an innovative oncolytic virus currently in clinical trials for pancreatic cancer.
Dr. Cascalló also serves as an independent expert for the European Medicines Agency (EMA), contributing to regulatory science and translational research. His career reflects a strong commitment to bringing cutting-edge science closer to patients.
📌 Join the seminar via Zoom: https://us06web.zoom.us/j/88680356896
Please share this event with colleagues and contacts who may be interested in attending.
by Comite Web | Nov 12, 2025 | Sin categorizar
At ALIPANC, we join once again World Pancreatic Cancer Day, which this year will be held on November 20th. This day is dedicated to raising awareness of a disease that is often diagnosed late and whose research still needs greater support. Today, we shine together with hope, supporting patients, families, and healthcare professionals, and remind everyone of the importance of recognizing symptoms, promoting research, and never losing our collective strength. We invite society as a whole to get informed, stand with us, and help spread this message: together, we are changingthe history of pancreatic cancer.
by Comite Web | Nov 11, 2025 | Sin categorizar
Between October 29th and November 1st, the Botton-Champalimaud Centre in Lisbon hosted the Second International Conference on Pancreatic Cancer. The three-day event brought together around 400 experts to discuss the latest advancements in oncology, surgery, and basic and translational research.
The conference offered sessions focused on translational research and clinical trials, highlighting how scientific breakthroughs are transforming clinical strategies toward more personalised medicine in the treatment of pancreatic cancer. Furthermore, the essential collaboration between basic science and clinical practice was emphasised. The consensus was that a deep understanding of tumour biology is fundamental for developing more effective treatments and, ultimately, improving patient prognosis.
Numerous members of Alipanc (the Spanish Association for Pancreatic Cancer Research) were present and showcased the latest results from their laboratories. Among the researchers who presented their work were Mariano Barbacid, Direna Alonso-Curbelo, Núria Malats, Francisco Barriga y Silve Vicent, along with many other colleagues from the association.
For more details on the complete conference program, visit: https://www.bcipcc.org/.
