by Comite Web | Jun 18, 2026 | Sin categorizar
A study led by the Hospital del Mar Research Institute and the IIBB-CSIC has identified a new strategy for treating pancreatic cancer based on inhibiting the PARP2 protein. The results, published in Science Advances, show in animal models that blocking this protein allows for a two-pronged attack on the tumor: causing cancer cells to die and facilitating the immune system’s response.
The study shows that genetic inhibition of PARP2 prevents cells from managing replicative stress, triggering their death. At the same time, it helps immune cells access and eliminate the tumor, which is particularly important in this type of cancer, considered a “cold tumor” due to its low immune response.
Furthermore, the results have been validated using patient data, reinforcing the potential of PARP2 as a new therapeutic target. Unlike current treatments targeting the PARP protein family—which are limited to a small subgroup of patients with mutations in genes involved in DNA repair—this strategy could benefit a significantly larger number of patients with pancreatic cancer.
The study paves the way for the development of specific PARP2 inhibitors, with the potential to combine them with existing treatments such as immunotherapy, thereby improving their efficacy and reducing side effects. Furthermore, this approach could be applied to other tumors with similar characteristics.
Reference article:
Neus Martínez-Bosch, Noemí Manero-Rupérez, Núria Vázquez-Bellón, Bennett Nickell-Hernández, Cristina Ventura-Blanch, Nura Lutfi, Carmen G Lechuga, Carlos Martínez, Mireia Moreno, Coral Ampurdanés, Etna Abad, Mar Iglesias, María Muñoz-Escribano, Ana Janic, Meritxell Rovira, Carmen Guerra, Gabriel A Rabinovich, José Yélamos, Pilar Navarro. PARP2 deficiency impairs pancreatic cancer progression by promoting genomic instability and antitumor immunity . Science Advances 2026; 12(19): eadu8849
by Comite Web | Jun 16, 2026 | Sin categorizar
September 25–26, 2026
Cruces University Hospital (Barakaldo)
A course designed to provide an update on pancreatology, combining theoretical and practical training, and covering the diagnosis, characterization, and management of pancreatic lesions through sessions led by specialists and hands-on clinical activities.
For more information: https://drive.google.com/file/d/1O8ILQseU3MQ_weqNnKGtwWPrByftJKaJ/view
by Comite Web | Mar 26, 2026 | Sin categorizar
Prof. Andreas Trumpp – ALIPANC Online Seminar
Speaker: Prof. Andreas Trumpp
Affiliation: German Cancer Research Center (DKFZ) & HI-STEM
Title: “Profiling and targeting of innervating peripheral neurons in pancreatic cancer”
(Profiling and targeting of peripheral neurons innervating pancreatic cancer)
Description
On April 13 at 14:00h CET, ALIPANC will hold a new session of the ALIPANC Seminar Series, an initiative designed to promote scientific exchange and highlight the most innovative advances in pancreatic cancer research.
Prof Trump is Head of the “Stem Cells and Cancer” Division at the German Cancer Research Center (DKFZ) and Founding Managing Director of the Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM) in Heidelberg, Germany. Trumpp is internationally recognized for his work on normal and cancer stem cells, particularly their roles in tumor initiation, therapy resistance, relapse, and metastasis. His research has provided key insights into stem cell dormancy and cancer stem cell biology, with translational implications for precision oncology.
Access
This seminar is open upon request in order to maintain an appropriate scientific environment.
If you are not a member of ALIPANC, please contact info@alipanc.org to request the meeting link.
by Comite Web | Mar 26, 2026 | Sin categorizar
ALIPANC researchers demonstrate that functionalization of lipid nanoparticles with “don’t eat me signal” blocking antibodies, such as the CD47/SIRP axis
α, result in a further increase of macrophage phagocytic activity on tumor cells.
In addition, enrichment of inflammatory M1 macrophages in preclinical PDAC models is achieved. These nanoparticles doubly functionalized with folate and the aCD7 antibody (LNP-FA-aCD7) allow the specific and efficient delivery of therapeutic mRNAs.
Pares et al. Biomed Pharmacother. 2026, 194:118919
https://www.sciencedirect.com/science/article/pii/S0753332225011138?via%3Dihub
by Comite Web | Mar 19, 2026 | Sin categorizar
The 3rd Scientific Meeting of ALIPANC brings together more than 80 experts to promote translational research in pancreatic cancer.
On March 13, the 3rd scientific meeting of ALIPANC took place at the HM Sanchinarro University Hospital in Madrid, with the attendance of more than 80 clinical and basic researchers.
In addition to the Keynote Lectures by Drs. Iván Ballesteros, Ignacio Garrido-Laguna and Elisabetta Mereu, there were invited presentations as well as a selection of the 29 papers received. Dr. Teresa Macarulla moderated a Round Table on collaborative research opportunities in the framework of clinical trials, with the participation of patient Mr. Richard Buck .
The high scientific level of the presentations as well as the discussions that followed should be highlighted.
All of us are summoned to the 4th ALIPANC Scientific Meeting, to be organized by Dr. Patricia Sancho in Zaragoza, Spain . We are waiting for you!
by Comite Web | Jan 23, 2026 | Sin categorizar
We are pleased to announce an upcoming seminar of special interest to the pancreatic cancer research community.
On Friday, January 23, at 12:00 noon (CET), Dr. Florencia McAllister, M.D., Associate Professor of Clinical Cancer Prevention and Gastrointestinal Medical Oncology at The University of Texas MD Anderson Cancer Center (Houston, TX), will visit the CNIO to give a scientific seminar, invited by Núria Malats.
Dr. McAllister is a physician-scientist and her research focuses on the intersection between tumor immunology, microbiome biology and pancreatic cancer pathogenesis. Her work has provided significant advances on how interactions between the immune system and the microbiome influence initiation, progression, therapeutic response and survival in pancreatic ductal adenocarcinoma (PDAC).
Title of the presentation
“Cancer as an Ecosystem: How Microbes Shape Tumors.”
How to attend
📍 In person (CNIO Auditorium)
It is necessary to bring your ID card or passport and to arrive 10 minutes in advance to facilitate access to the building.
💻 Online via Zoom
Date and time: January 23, 2026 – 12:00 h (Madrid time)
🔗 Zoom Link: https://cnio-es.zoom.us/j/64090466393?pwd=0KhXbr1pUdGtQ2ERxtjiO6IpbqYPpU.1
Meeting ID: 640 9046 6393 Access code: 468662
We look forward to your participation in this interesting seminar.
