Metabolism and Tumor Stem Cells
Basic/translational research
Instituto de Investigación Sanitaria Aragón (IIS Aragón), Miguel Servet Hospital
·Zaragoza ·

We are a basic and translational research group mainly focused on pancreatic cancer. We used patient-derived models both in vivo (PDXs) and in vitro (PDOs, primary cultures of PDXs), as well as orthotopic models with cells derived from the KPC model, to study the impact of tumor metabolism and intratumoral heterogeneity on treatment resistance.

We focus on the search and validation of new drug targets, always favoring drug repositioning. We currently have several ongoing projects to evaluate the role of lipid metabolism in treatment resistance and tumor stem cell function.

Main publications in pancreatic cancer:

  1. Parejo-Alonso B, Royo-García A, Espiau-Romera P, et al. Pharmacological targeting of the ALK receptor inhibits tumorigenicity and overcomes chemoresistance in pancreatic ductal adenocarcinoma. Biomed Pharmacother: 158: 114162. doi: 10.1016/j.biopha.2022.114162
  2. Courtois S, Luxán-Delgado B, Penin-Peyta L, et al. Inhibition of Mitochondrial Dynamics Preferentially Targets Pancreatic Cancer Cells with Enhanced Tumorigenic and Invasive Potential. Cancers (Basel). 2021; 13(4): 698. doi: 10.3390/cancers13040698.
  3. Espiau-Romera P, Courtois S, Parejo-Alonso B. Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification. J Clin Med. 2020; 9(12): 4128. doi: 10.3390/jcm9124128.
Patricia Sancho

Principal Investigator

Group members

  • Patricia Sancho

Other groups