Clinical Diagnostics and Molecular Interactions (BIFI-UNIZAR)
Basic/translational research
University of Zaragoza-Institute of Health Research of Aragon
·Zaragoza ·

We carry out projects related to the development of new diagnostic tools in cancer based on thermal liquid biopsy (TLB), the identification of bioactive compounds against various pathologies, and the use of polymeric nanostructures in therapy and diagnosis.

Main lines of research:

  1. TLB (Thermal Liquid Biopsy) applied to tumor pathology diagnosis: validation of a new rapid and non-invasive diagnostic method.
  2. Evaluation of polymeric nanostructures that can be used in drug delivery or specific detection of serum biomarkers.
  3. Identificación y caracterización de compuestos bioactivos frente a distintas dianas proteicas: NuPR1 (cáncer de páncreas), BFT3 (infección por Bacteroides fragilis), MeCP2 (Síndrome de Rett).
  4. Application of machine learning models to the analysis of clinical and biological data.

Main publications in pancreatic cancer:

  1. Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma Neira J.L., Bintz J., Arruebo M., Rizzuti B., Bonacci T., Vega S., Lanas A., Velázquez-Campoy A., Iovanna J.L.& Abian O. Scientific reports, 2017, 7:39732 DOI: 10.1038/srep39732.
  2. Thermal Liquid Biopsy (TLB) Focused on Benign and Premalignant Pancreatic Cyst Diagnosis. Hermoso Durán S, García-Rayado G, Ceballos-Laita L, Sostres C, Vega S, Millastre J, Sánchez-Gracia O, Ojeda JL, Lanas Á, Velázquez-Campoy A, Abian O. J. Pers. Med. 2021, 11 (1): 25. doi.org/10.3390/jpm11010025. 
  3. Repositioning small molecule drugs as allosteric inhibitors of the BFT-3 toxin from enterotoxigenic Bacteroides fragilis. Jimenez-Alesanco A, Eckhard U, Asencio Del Rio M, Vega S, Guevara T, Velazquez-Campoy A, Gomis-Rüth FX, Abian O. Protein Sci. 2022 Oct;31(10):e4427. doi: 10.1002/pro.4427. 
Olga Abian Franco
Adrián Velázquez Campoy

Principal Investigator

Group members

  • Olga Abian Franco
  • Adrián Velázquez Campoy
  • David Ortega Alarcón
  • Sonia Hermoso Durán
  • Ana Jiménez Alesanco
  • Sonia Vega Sanchez
  • Marta Asencio del Río
  • Paula García Franco
  • Hajar Jeblaoui
  • Judith Millastre Boscos
  • Violeta Morcuende Ventura
  • Natalia Abian Franco
  • Oscar Sánchez Gracia

Other groups